Sacubitril/valsartan in Heart Failure and Beyond—From Molecular Mechanisms to Clinical Relevance
نویسندگان
چکیده
As the ultimate pathophysiological event, heart failure (HF) may arise from various cardiovascular (CV) conditions, including sustained pressure/volume overload of left ventricle, myocardial infarction or ischemia, and cardiomyopathies. Sacubitril/valsartan (S/V; formerly termed as LCZ696), a first-in-class angiotensin receptor/neprilysin inhibitor, brought significant shift in management HF with reduced ejection fraction by modulating both renin-angiotensin-aldosterone system (angiotensin II type I receptor blockage valsartan) natriuretic peptide (neprilysin inhibition sacubitril) pathways. Besides, efficacy S/V has been also investigated setting other CV pathologies which are during their course progression deeply interrelated HF. However, its mechanism action is not entirely clarified, suggesting off-target benefits contributing to cardioprotection. In this review article our goal was highlight up-to-date clinical experimental evidence on cardioprotective effects, well most discussed molecular mechanisms achieved dual-acting compound. Although extensively patients, additional large studies needed elucidate effects conditions. Furthermore, antiinflamatory potential, agent should be animal models inflammatory diseases, such myocarditis, while it possibly improve cardiac dysfunction response setting. Also, discovering signalling pathways affected particular interest for basic researches, can provide understanding mechanisms.
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ژورنال
عنوان ژورنال: Reviews in Cardiovascular Medicine
سال: 2022
ISSN: ['2153-8174', '1530-6550']
DOI: https://doi.org/10.31083/j.rcm2307238